EMT/MET reporter cell lines: Elevating biological models of metastasis

Epithelial-to-mesenchymal transition (EMT) and its reverse (MET) are physiological mechanisms implicated in cancer metastasis. To provide researchers with advanced biological models to study these phenomena, ATCC scientists used their mastery of CRISPR/Cas9 technology to create a number of gene-edited EMT and MET reporter cell lines. These reporter lines enable real-time monitoring of the transition of cells from epithelial to mesenchymal state (or the reverse) via the expression of red fluorescent protein (RFP)–tagged vimentin or green fluorescent protein (GFP)–tagged E-cadherin. This webinar will provide an overview of ATCC’s EMT/MET models and highlight the compelling transition data that was revealed in their development and validation.



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