Elevate Your Toxicity Assays: New Models with Biological Relevance and Predictability

Thursday, April 15, 2021 12:00 PM - 1:00 PM ET

Abstract:

Designing cell-based toxicity assays can be challenging; large numbers of cells are needed to satisfy the throughput of the assay, yet the cells must be physiologically relevant for the assay to be predictive. While primary cells exhibit the highest biological relevance, hTERT-immortalized primary cells exhibit the growth characteristics of continuous cell lines with physiological attributes of primary cells. In this webinar ATCC scientists discuss the characteristics and utility of various respiratory, skin, and kidney models in toxicological assays. Additionally, the speakers present data that demonstrates that these modified primary cells are effective tools that provide tissue-relevant results and reproducibility for any cell-based assay, including toxicology assays.

Key Takeways:

  • hTERT-immortalized primary cells are comparable to primary cells regarding physiological relevance, but are able to avoid replicative senescence.
  • Using well-characterized hTERT-immortalized cells, ATCC has created credible cell models for toxicological studies on the kidney, skin, and airway.
  • Our data show that these modified primary cells are effective tools that provide tissue-relevant results and reproducibility for any cell-based assay, including toxicology assays.


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